Cell
division:
-
The
cell life cycle has two major parts, being interphase and mitotic phase,
or cell division. Although the term "interphase" leads one to believe that
it is not but a resting period, this is not true. During interphase, which
is the longer of the two, the cell is quite active, resting only from division.
A more accurate term would be metabolic phase
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The
purpose of mitosis is to produce more cells for growth and repair purposes.
It is essential that the resulting cells both have the same genetic material,
the deoxyribonucleic acid (dna) is duplicated near the end of interphase.
DNA is made up of nucleotides arranged in a double helix. Each helix is
bonded to the other via hydrogen bonds between the nitrogen bases of the
nucleotides. An enzyme untwists the helixes, and splits them apart. Each
half is a template for re-building the other side. Adenine to thymine,
guanine to cytosine. The fist part of cell division is mitosis, the division
of the nucleus and it's contents. The second is cytokenesis, the division
of the cytoplasm, which takes place near the ending of mitosis. Mitosis
itself is made up of four stages:
-
Prophase
it the first stage, in which the chromatin threads coil and shorten int
visible, bar-like structured named chromosomes. Since dna replication has
occurred in interphase, each chromosome is actually of two strands, each
known as a chromatid, and held together by a body called a centromere.
The centrioles begin to migrate to opposing ends of the nucleus, and directing
the construction of mitotic spindles between them. These spindles form
structures which will be used to pull the chromosomes apart. By the end
of prophase, the nuclear membrane and the nucleoli have broken down and
disappeared, and the chromosomes have become attached to the spindle fibers
at the centromere
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In
metaphase, the chromosomes cluster and become aligned at the center of
the spindle fibers, forming a straight line of chromosomes that can been
seen
-
During
anaphase, the centromeres split, and release the two chromatids- now called
chromosomes again- to be pulled by their half-centromeres towards opposite
centriols
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Anaphase
is finished when the chromosome movement has ended Telophase is the last
phase of mitosis. The chromosomes at each end of the cell uncoil, and become
the thread-like chromatin once more. The spindle fibers break down, and
a nuclear membrane forms about each chromatin mass. The nucleoli appear
in each of the daughter cell nuclei
-
Cytokenesis
begins during late anaphase and ends during telophase. A cleavage furrow
appears over the midline of the cell, and squeezes or pinches the original
cytoplasmic mass into two parts. Each resulting daughter cell is slightly
smaller than the original, but is genetically identical to it. The cells
grow and carry out normal cellular activities until it's time comes to
divide.
-
Although
nucleus and cytoplasmic division usually go together, in some case, such
as liver cells, cells become binucleate or multinucleate cells. When mitosis
"goes wild", the result is cancer
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