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Genetics Not Significant To Developing Typical Parkinson's Disease

WASHINGTON, MD -- Jan. 27, 1999 -- Genetic factors do not play a significant role in causing the most common form of Parkinson's disease (PD), according to a study published in today’s issue of the Journal of the American Medical Association.

This epidemiological study, the largest of its kind to investigate the role of genetic or environmental causes of PD, examined 19,842 white male twins enrolled in a large registry of World War II veteran twins.

"This study cuts a wide swath of research opportunities into causes of Parkinson's disease by suggesting that heredity is not a major etiologic component in the largest group of PD patients, those whose disease began after age 50," said Michael Walker, M.D., director of the division of stroke, trauma and neurodegenerative disorders at the National Institute of Neurological Disorders and Stroke (NINDS).

For many years, researchers have speculated about the causes of PD, with the primary considerations being genetic determinants and environmental factors. The current study suggests that typical PD -- defined as PD diagnosed after age 50 -- has no genetic component, while the opposite was observed in a small subset (six pairs) of identical and fraternal twins whose PD was diagnosed before age 51 in at least one twin. Investigators concluded that undetermined environmental factors, not genetics, are likely triggers of typical PD and they suggest that research concerning a genetic link to PD be directed toward subjects with earlier onset of the disease.

Twin studies have proven particularly useful in distinguishing the relative contributions of genetics and environment to the cause of various diseases. In the JAMA study, the investigators theorized that if PD had a genetic basis, both individuals in an identical twin pair would be expected to develop the disease (since they have the exact same genetic make-up). Instead, they found that PD most commonly occurred in only one member of a twin pair, whether the pair was identical or fraternal.

"Since purely genetic Parkinson's disease appears to be rare, investigations of genetic forms of parkinsonism, such as in families with multiple-affected generations, will help us to identify the underlying disease mechanisms," said principal investigator Caroline Tanner, M.D., Ph.D., of The Parkinson's Institute in Sunnyvale, CA., and the study’s lead author.

Study subjects were part of the National Academy of Sciences/National Research Council World War II Veteran Twins Registry, which consisted of 15,924 pairs of white male twins when established in 1959. This study attempted to contact all 19,842 individual twins believed to be alive as of 1992. Pairs were excluded if both twins could not be located, refused to participate, or were known to be dead. If one twin was eligible and the other refused to participate, had dementia, or was dead, a proxy informant was used, either the participating twin brother, a previously provided contact, or a commercially available database.

 In brief interviews, all study subjects received screening for suspected parkinsonism, dementia, cerebrovascular disease, eye disease, cancer and possible risk factors for these diseases. This cohort was ideal for the study, as they had reached an age range of increasing risk for PD. Twins diagnosed in the study as having possible or probable PD were found to exhibit at least two of the four standard symptoms of parkinsonism -- tremor, rigidity, postural instability and bradykinesia (gradual loss of spontaneous movement).

More than half a million Americans have PD, a chronic and progressive motor system disorder that strikes men and women almost equally. The disease usually affects people over age 50, with the average age of onset at 60 years. Up to 50,000 new cases are diagnosed each year. Currently the disease has no cure; standard treatment usually involves the drug levodopa, or L-dopa, but symptoms may return following long-term use of this drug.

Thanks to The Doctor's Guide to the Internet™ for the article


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